Not sure if you're talking about applying for a position remotely, or just starting doing it. If you're thinking about doing it with your current employer, I have a few recommendations:
Have a good plan for socializing. I've been doing remote work for six years. It gets lonely, and I'm on the introverted side.
Other than that, make sure you have a decent setup at home as far as desk, comfortable ergonomic chair, the right communications methods (phone, chat, whatever), fast internet. Also, make sure you are disciplined enough to actually work without getting too distracted. And I can't emphasize enough having a UPS for when the power goes out.