Larvol Cliniclarvol.hashnode.dev·Aug 29, 2024Study on Non-Inferiority of ESP vs. PVB for Pain Management in Unilateral Mastectomy with Immediate ReconstructionThe objective of this study is to assess the non-inferiority of analgesic efficacy of ESP vs PVB for patients undergoing unilateral mastectomy followed by immediate reconstruction. Detailed Description n breast cancer treatment, surgery plays a centr...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Aug 23, 2024Impact of IDH2 Variants and Co-Mutations on Survival in Relapsed/Refractory AMLAbstract Limited treatment options are available for patients with relapsed/refractory acute myeloid leukemia (R/R AML). We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free surviv...DiscussTumor
Larvol Cliniclarvol.hashnode.dev·Aug 23, 2024Phase I Study of ARX788 in HER2-Positive Metastatic Breast Cancer: Safety, Pharmacokinetics, and Antitumor ActivityAbstract Purpose: ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibo...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Aug 8, 2024Phase I Study of ARX788 in HER2-Positive Metastatic Breast Cancer: Safety and EfficacyPurpose: ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibody. Herei...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Aug 8, 2024Hypofractionated Radiotherapy with Temozolomide and Bevacizumab in Glioblastoma: Phase II Trial ResultsPurpose: Bevacizumab is associated with decreased vascular permeability that allows for more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed glioblastoma utilizing a novel hypofractionated stereotactic radiotherapy...Discussbreast cancer
