Sangeerththan Balachandransangeerththanbalachandran.hashnode.dev·Nov 9, 2024Yoga for healthy Life.Today I am going to discuss regarding an important topic which is becoming a healthy software engineer. I have created a routine of yoga activities which will be immensely useful for the mental and physical balance as a software engineer. The Yoga Ro...Discuss·89 readsyoga
Larvol Cliniclarvol.hashnode.dev·Sep 27, 2024Gilteritinib Plus Azacitidine for Newly Diagnosed FLT3-Mutated Acute Myeloid Leukemia: Phase 3 Study Design and Preliminary ResultsBackground: Gilteritinib is an oral FMS-like tyrosine kinase 3 (FLT3) inhibitor that has demonstrated efficacy with favorable tolerability in patients with FLT3-mutated (FLT3mut+) relapsed/refractory acute myeloid leukemia (AML), including internal t...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Sep 20, 2024Impact of Endocrine Therapy Timing on Disease-Free Survival in Breast Cancer: Insights from the UNIRAD Phase III TrialAbstract Background: Circadian rhythms regulate cellular physiology and could influence the efficacy of endocrine therapy (ET) in breast cancer (BC). We prospectively tested this hypothesis within the UNIRAD adjuvant phase III trial (NCT01805271). Me...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Aug 16, 2024Sequential Sacituzumab Govitecan and Talazoparib in Metastatic Triple-Negative Breast CancerAbstract Purpose: The antibody-drug conjugate (ADC) sacituzumab govitecan (SG) comprises the topoisomerase 1 (TOP1) inhibitor (TOP1i) SN-38, coupled to a monoclonal antibody targeting trophoblast cell surface antigen 2 (TROP-2). Poly(ADP-ribose) poly...DiscussTumor
Larvol Cliniclarvol.hashnode.dev·Aug 16, 2024Phase I Study of ARX788 in HER2-Positive Metastatic Breast Cancer: Safety and EfficacyAbstract Purpose: ARX788 is a novel antibody-drug conjugate (ADC) comprised of an anti-HER2 mAb and a potent tubulin inhibitor payload AS269 that is site-specifically conjugated to the antibody via a nonnatural amino acid incorporated into the antibo...DiscussCancer
Larvol Cliniclarvol.hashnode.dev·Aug 8, 2024Hypofractionated Radiotherapy with Temozolomide and Bevacizumab in Glioblastoma: Phase II Trial ResultsPurpose: Bevacizumab is associated with decreased vascular permeability that allows for more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed glioblastoma utilizing a novel hypofractionated stereotactic radiotherapy...Discussbreast cancer
Larvol Cliniclarvol.hashnode.dev·Aug 8, 2024Trial: Ponatinib vs Imatinib in Ph+ ALLImportance: In newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits...DiscussCancer
