How do I build a Node.js API-based website, with a separate front end that doesn't use a front-end framework?

I don't want my web application to get caught up in the forever changing Front End frameworks and libraries. I just want something simple that any developer can work on that isn't always changing. I was thinking of going the route of EJS , Jquery, and Pjax on the frontend but not sure how this would work with a completely separate backend. I do want future versatility based on it's design if we decide to build a mobile app (Reasoning for API based). I realize that this is an SPA design and I can't seem to find any research on MPA restful websites. The website I'm making is a Reddit clone, so will be user interaction on the front end.