I don't have a degree. The only times I've had a tough go finding a job is when I've lived in places with crappy tech markets - and even then everyone has a tough go in those areas.
I've beaten out people who hold master degrees for jobs (though I'm sure I've also lost plenty of jobs to people with degrees as well). On the other side of the interview table, I've yet to see a candidate where the fact they have a degree is the only thing that sets then apart. You either know what you're doing or you don't, and the degree gives you a start but it's not the only way in.
The only thing I can tell having a degree would have gotten me is bigger paychecks sooner. I've had managers tell me that a degree was literally the only thing keeping me from a raise - not the skills it would give, because you can learn those anywhere. Having the degree. (That was also at a job I only applied to because they forgot to mention in the requirements that a degree was needed - they gave me the job anyways.)
Not having a degree has definitely contributed to my imposter syndrome, but in turn it's also made me work harder to learn stuff on my own time so that I can hold my own with everyone else. YMMV.