Yup, VueJS and Python Flask.
Like Grigorii K. Shartsev said, the server code doesn't really have any effect on how the frontend interacts with it: they both speak HTTP, and as long as your API design is the same, it's the same as if you were using, say, NodeJS.
I have used Django and VueJS in fact you can setup a simple implementation of this with this boilerplate: github.com/NdagiStanley/vue-django Yashu Mittal