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It would be dependant on the 'success or error methods that get called upon return of an API call. So something like this:

ajax({
    method: 'POST',
    url: "/dostuff",
    data: postObject,
    success: function(response){
        // Do nothing - post has been successfully accepted.
    },
    error: function(response){
            // Uh oh
            node.textContent = "Try again, the post didnt submit";
    }
});