I use Arch, debian, ubuntu, fedora.
well there is no more brew and you will have to use apt-get / apt-cache. the unity desktop is different but you can style it close to mac.
you will have no photoshop, adobe stack.
if you use the AWS cloud the PSK wont work out of the box. you will have to use strongswan.
that's all i know of :) i know i like linux more than all the others :)