CSS3 is widely supported today, but it's definitely important to check browser support for the set of technologies you and your workplace are supporting. This is an important conversation to have at work/with your client (the exact tech stack of browsers you're supporting).
With that in mind, make choices that can reflect this decision. Then, be sure to test on various browsers and systems. Sometimes you find weird bugs on Chrome for Windows or IE10 that you weren't anticipating. Browser testing is the best way to uncover and resolve these.