React is the view library - so it can be used with any tech stack. At Hashnode we are using Node/Express, MongoDB and React. Further if you combine Flux architecture with React then you'll have a good architecture in place. But it totally depends on your preferences.

Yeah, the MERN stack ... I'm using this in one of my projects. Has worked well so far, but the express / node layer is very thin. I could have used restify instead of the heavyweight express with little or no difference. I did not find a need to use Flux.

I wrote up this tutorial when trying to come to grips with this stack, if you're interested.