Do you sometimes think: "Ohh, this feature is missing in APEX Builder"? Me too, very often. APEX Team is doing a great job, but they can't create every feature we want (yet?:). How do you remove all unnecessary List of Values with one click? Recently...

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Jeffrey Kemp
Interesting article - digging into internals is always enlightening.
The question you asked at the end - I asked that very question too. And the answer, in hindsight, seems obvious - since every APEX application is nothing more than rows stored in metadata tables, the earliest APEX components were built by directly running SQL or calling the very PL/SQL APIs that the Builder itself calls to create and edit them for you!