Single-Cell DNA Sequencing Reveals Clonal Dynamics in FLT3-Mutated Acute Myeloid Leukemia during Crenolanib Combination Therapy

BackgroundSingle cell RNA (scRNA) sequencing analysis suggests that the presence of FLT3-ITD mutation is associated with a progenitor-like phenotype (1van Galen, et al. Cell, 2019: 176, 1265) while activating mutations in the FLT3 kinase domain are a...