Just in case other people run into this: I was getting 403's when I implemented the solution in this blog. It turns out that my company uses a different datadog enpoint than the default. So if you're using a different one, here's how to configure it: const configuration = client.createConfiguration({ authMethods: { apiKeyAuth: "pub..." , }, }); configuration.setServerVariables({ site: "us5.datadoghq.com" }); const apiInstance = new v2.LogsApi(configuration);