ES6 conventions and features. It's here and it's supported, so learn it. Angular 2. It's not my cup of tea, but it's very much in demand. If you want employment flexibility, Angular 2 is important. CSS grids. Support for them is starting to land, and they are a game changer. ReactJS. Nearly as in demand as Angular. It would behoove you to know it. VueJS. Vue is going to pick up a lot of momentum over the next couple of years. It's a great framework and the learning curve is much easier than ng2. Probably the most important thing is just to spend time mastering plain ol vanilla JS and learning good design practices.