There might be some advantages when you are in a team where everybody is focused on JS. The Isomorphic way of doing stuff today isn't the best option if you ask me. I prefer to develop applications where the frontend is only the client and it talks to some Api. Once you start doing this there is no reason to use node.js over and over again. The Microservice Architecture of modern Webapps allows you to develop each service in the language you like to, together with Docker this is unbreakable. Every language has advantages on different scenarios, so beeing able to build any service of you App in any language you like is a major advantage. And i you grow, it's even easier, you do not NEED to search for a node.js dev, you need a dev who can build a service in whatever language he likes, as long as it runs fine it's ok.
So i don't think you have any advantages in building everything in the sam language, it's even better to split everything up. But if you are restricted and everything is running on ONE Server with a Monolith Architecture, then i'd also think about using one language.. ;)