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Yes, you can use mobx.map for this. With mobx.has you can observe not-yet existing properties

const store = map({test1: null});
autorun(() => {
  if (store.has("test2")
    console.log(store.test2);    
});
store.merge({"test2": "aaa"});

EDIT Object changes (including adding observables) can also be detected by using

const store = observable({test1: null});
mobx.observe(store, (change) => {
  if (change.type === "add")
    console.log("attribute " + change.name + " was added!")
});
extendObservable(store, { test2: "aaa" });