I guess you mean javascript frontend frameworks like angular, ember etc. right? And not stuff like bootstrap or foundation?
Well it depends on two things. Do you have a solid API? And do you have enougth interactions where a Frontend Framework would simplify things.
The project size however is not that important. You can use frontend frameworks on small projects, too. If the user benefits from it.
The cool thing with for example React or VueJs is that you can build small components and there is no need to build the whole frontend as a SPA with that framework.