I started web developing in 1999 with Flash 4. Before that I did some fiddles with Commodore 64 and later with MS-DOS Basic. After Flash I learned some PHP, but I can't say I ever mastered it.
Node.js I started with in 2011 and have done all my projects using Node.js since. I use MongoDB as a database.
My biggest lesson have been keeping it simple. Using fullstack JavaScript works best for me, since I understand every little detail that's happening in the backend and frontend. I don't need to switch between mindsets and because I'm using MongoDB I have fullstack JSON as well. I never learned those confusing SQL-languages, so I was thrilled when MongoDB came out. Best language is the one you know best.
Another advice: have fun! Fiddle around, do side projects, play with new ideas.