ES6 is just a JavaScript today and you don't need to do anything to init it. All tutorials you see today, of course, are written in modern language and you may and have to write the same way today. ES6 is supported by any modern browser, however, it is still recommended to transpile ES6 into older ES5 and only if you need to support older platforms.
To do so you can use Assets Builder which gives you all tools you need for modern web development out of the box. Just node build js and it works.
If you will need any support, please feel free to ask on our Gitter channel.
If you need ES6 server-side, then you can use it with latest Node version without transpilation, however, you still have to use require() syntax instead of import/export.