No.
There is more than express. But express has the biggest ecosystem.
If you look on other frameworks, you should maybe look if you could use express middleware within it.
If you want more comfort, loopback is something you can look on (it’s build on express).
Koa was built as a renewed express. It gives you more possibilities and a higher performance. The V2 uses ES2017 features but can also used with ES2015. it has an own ecosystem. But is possible (not always easy) to use express middleware. I like it.
Some days ago someone posted an article on hashnode that contained a reference on a new framework called spirit. It is in early development but has an outstanding potential. Express middleware is easily pluggable. It could be replace express in the future completely.