By DOM Manipulation, I presume that you mean the direct DOM manipulation. The answer is Yes... well, for the most part.
If you were to work third party libraries like D3.js, which demand control of the parts of the DOM, which they render to, then the answer is No! You would have to make accommodations so that these libraries can play well with ReactJS.
...and when you do have such a scenario to deal with, you should use Refs to access the DOM node of the correspondent React element. 👇