I think you're missing the entire point.
First, what do you want to build? A web backend that's fast? Productive? Scalable? Or a combination?
Secondly, what languages do you know? Which of them do you think can get the job done? Has python ever made you fast in building stuff. Has Javascript made you more productive?
Next, get the best framework that gets it done. There are lots of framework out there for a reason. Or write your own, if not.
If you like Javascript Nodejs, try NestJS nestjs.com