I voted no from my own personal perspective, because I'm more a UX/UI designer and I do not rely on anything related to Node. No LESS/SASS, no complex JS stuff, no APIs... But that's okay I guess. I've played with Node for a bit (the backend part), but it's not something I need ;)
My advice: take a good look at Node and see if it can work for you. If it does, use it! :)