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Purely depends on what technologies you are working on. Here is what I use :

1. Angular - Jasmine & Karma for Unit Testing. Protractor for E2E tests.
2. Node.js - Mocha
3. EmberJS/jQuery/plain JavaScript - QUnit
4. React - Jest
5. Meteor - Velocity and Gagarin
6. Polymer - web-component-tester which uses Mocha and Chai behind the scenes.