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You should check out Typescript. With that I don't use it with my Nodejs but might try to implement it. Angular 2 the front end I know extremely well uses typescript and wow it made developing front end a breeze and I honestly think it's the future of javascript. PS. it compiles down to javascript in the end.

I've used TypeScript, it feels like a type system was bolted on (not great, but still better than pure JavaScript) and you still have to deal with the JavaScript quirks. Dart seem to be the perfect fit for Java developers looking to escape the nasties of JavaScript; been using Dart for close to two years now,

Aswell as Typescript/Coffee there is Dart and Scala.js which transpile to JS. I'm not sure how these compare or how well they perform, but the fact is there are plenty of alternatives for developers that just don't like JS. I'm one of those developers, but I've not used any of the above professionally.

And soon Kotlin which seems to be planning to target Web Assembly which in the long run might be a better move for them than focusing too much on their KotlinToJS transpiler. Kotlin Serverside is already great, getting Kotlin to WASM would be super!