What you're feeling is not uncommon. There's even a name for it: JavaScript fatigue.
My advice: pick one opinionated framework and stick with it. On the backend go with Node and Express. On the frontend, I would recommend Angular 5 (which I'm sure many will disagree with). Angular is far more opinionated than React, is a more encompassing framework, and makes more of the technologies choices for you. It's larger in size than React because it bundles more supplemental libraries with itself. The Angular CLI will provide everything you need to make even sophisticated apps including tooling to automatically generate new project assets like components and services.
If you're already entrenched in the React world, you might try to find a robust and opinionated starter kit that has made most of the choices for you. Not being a React developer myself, I'll have to defer to someone else for such a recommendation.