If the question is taken literally, a perfect solution would be designing a swagger spec in YAML using swagger(now OpenAPI) standards and using any third-party service to create and host the application. RAML would also be another option here. In Python there are several libraries, some of which even can open a simple single call API in 3-4 lines of code -- quick enough?
If we'd have to choose between REST API frameworks to develop an application with heavy business logic, in my opinion Loopback is the way to go. It will help you keep the API completely in compliant with the swagger specs. It can automatically generate the YAML file if you require. All you have to do is create data schema in JSON. It can generate client SDKs, for example the a services.js file would be generated if in case of angular.
Lot of popular MVC frameworks like Django added additional libraries for generating REST APIs. But the middleware involved in the request-response cycles is still there. That'll definitely do unnecessary work at times and increase latency. I prefer to stay away from them than digging deep to disable the middleware.