React/ Angular at frontend with NodeJs/Spring at backend , powered by either MongoDb/ Postgre .. this is the most widely used and popular stack for development of enterprise level applications with high availability and stability.
Snapdeal, Flipart, Airbnb, Myntra, AOF all are using React with Node...
All mentioned are well established technologies and have the most community support. So, for hiring perspective you can get developers easily, Stackoverflow questions, existing community is also active for these technologies.
However, if you want to try something new (not that new :P) try Meteor. Its available for both client as well for backend.