I don't mind ads per se. I hate when an add pops up over content I'm in the middle of reading. It's rude. When a site does that, I often nope outta there.
That said, aside from an ad-blocker, I also put common ad domains into my local DNS pointing to 127.0.0.1. This speeds up loading time for numerous sites, and results in a simple 404 not found error from my own server.