If you are using any framework, you can directly hire a developer who is proficient in same and get started more quickly; which is very unlikely in VanillaJS apps.
So the Bus Factor and Organizational risks can be avoided or reduced.
Other than that, there is no huge advantage.
I use frameworks for throwaway projects.
When I am sure about the longterm, I would rather spend time in deciding what can I afford to have as a library or utility in my app.