Well for example, I spent 60 minutes yesterday because my /boot/ partition was full so apt-get didn't work.
You have to balance disadvantages like that against the benefit, which is being able to customize everything, saving a few dozen euros, and maybe better dev tools.
I like Ubuntu, but I never recommend it to people who aren't programmers. Their only relevant advantage is saving a few dozen euros at the cost of weird problems they can't solve, and games and Office being difficult.