What you would need is the following:

1. GPU's
2. A wallet of the cryptocurrency of choice
3. A "mining pool" for the cryptocurrency of choice
4. Mining software for the cryptocurrency of choice

For the advanced:

1. A custom BIOS
2. Custom config/GPU acceleration
3. Check which cards have the best hash rate and best power per hash and best initial value per hash.
4. Check the cost of hash/watt which equates to profit per hour or day.
5. Custom automatic profit switching system to switch cryptocurrencies

whattomine.com

That should get you started. However, be aware that investment/mining is of your own mind and you can't blame anyone if the whole thing tanks.

well best would be 10 years ago ;D ... now the bubble is building and basically we can all look forward to the next economy crash :)..... besides that .... get cheap electricity and a lot of GPUs ;)