Well, what's your use case? If IE11+ is only 10% of your target market then great go for it, and bare in mind the points @maruru makes. Otherwise you'll need to include shims/polyfills. I'm pretty sure there's a way around this though, something about setting it's z-index: 999999 and draggable == true (or something like this). Depends if you want to do anything fancy with it.

I had to make an application with drag and drop with the same requirements some time ago, but I decided against the API, because it was limited and IE11/Chrome still do not support many convenient features. That leaves you with a lot of JS either way, so I just implemented a custom JS solution.

As for IE11, limited features include (taken from CanIUse):

• no dropzone attribute
• not supporting .setDragImage()
• limited supported formats for dataTransfer.setData()/getData()