I prefer TAP and TAPE. They are simple and do not waste my energy with making me search for documentation. Everything I need in one place, foolproof.

const tape = require('tape');

tape('timing test', t => {
    t.plan(2);

    t.equal(typeof Date.now, 'function');
    var start = Date.now();

    setTimeout(function () {
        t.equal(Date.now() - start, 100);
    }, 100);
});

Framework: Ava

Because it has a short, effective and modern Syntax. It runs its tests in parallel (very fast).

Runner: Wallaby

Best editor integration ever. Live tests and feedback.