I don't know how you do event handling (maybe you could share some code), so I will assume you are using standard HTML event handling.
const target = document.querySelector('canvas')const handler = function() { /* ... */ }target.addEventHandler('event-name', handler)target.removeEventHandler('event-name', handler) (docs)You should make it a habit to clean up everything after use, the latest on shutdown of your main code, especially if you do not stop the program, as in your case.